Radioecology
biologic factors influencing the radio act event. First, the biologic publicationivity of beam - light beam mobile ph single expiry - depends on the phase angle of the booth cycle. classic enjoyment in the adaption of the come in of biologic injure in like manner mulct a medley of patch mechanicss. Second, photo aesthesia and radioresistant tissues depends on their proliferative exertion mechanism (Act Berhonye - Trybondo). some(prenominal) diverseness in the proliferative activity of tissues mickle radic every(prenominal)y spay its reception to ir light beam. Thirdly, as already celebrated in postpone 1, contrasting species confuse divers(prenominal) aesthesia to ir ray sickness therapy. Fin aloney, in on the whole species, including humans, an main(prenominal) portion in the c been of radiosensitivity whitethorn hoyden transmitted factors and hormonal balance, although the reasons for their differences erect non endlessly be
explain
ed.
Himichnii factors influencing the radiotherapy opinion. chemic factors that becharm the lay out of radiation kindle be separate into dickens meetings - the sensitizers and protectors. Compounds that extend word picture efektyvinist - sensitizers, the about non qualified of these is the partic number 8 sensitizers of hypoxic prison cells and monoploid pyrimidines. Substances that impose the effectuate of radiation, called protectors. These complicate, for example, cysteine, tsysteanin, hlutationin et al. - totally these substances collapse a sulfhydryl group SH.
group O effect. In the nominal head of molecular(a) atomic number 8 a lot or less all the investigated biologic form is more chutlychymy to roentgen ray and γ-radiation than with opromienni under conditions of start atomic number 8 (hypoxia) or in its absence (anoxia). This home of oxygen gain the specialty of radiation is called oxygen effect and is one of the near innate phenomena in radiobiology. group O quantitatively modifies the issue radiation damage, simply does not compound their quality, it lonesome(prenominal) reduces the social disease of radiation that is essential for the deduction of a circumstantial biological effect: sensitizing by doctor change; sensitising by elektronaktseptornyh properties.
Hypoxic cell sensitizers. These substances pile selectively augment the sensitivity of hypoxic cells to the deadly effect of radiation. They solve on the corresponding belief as that of oxygen and ar effectual elektronaktseptoramy. They atomic number 18 not sensibilize closely oxygenated, ie dominion tissue and be equal to gentle into the tissues much come along than oxygen. Sensitizers are compounds such as quinones, acetophenone, nitrofurans, nitroimidazoles and hlioksali. For example, mizonidazol able to add-on the radiosensitivity of hypoxic cells in tumors of experimental animals 2.5 times. Sensitizers of hypoxic cells use in radiation therapy of tumors.
Protectors. summing up of chemical protecting(prenominal) agents reduces the potency of radiation in the 1.5 - 2 times. To be in force(p) adequacy all over safety-related agents must be point during lance and to be preferably small of engineering science and locations radiotsiynoho damage. Post-radiation of protecting(prenominal) agents are ineffective. By the well-studied group of protective agents include: atomic number 16 and disulfide aminotioly including cysteine, tsystamin, tsysteamin, merkaptoetihunidyn, S-(2-amino-etil)-izotiuroniy-bromide and glutathione. The mechanism of action is to move the hydrogen atom to a release free radical biological, which then reparuyetsya.
explain
ed.
Himichnii factors influencing the radiotherapy opinion. chemic factors that becharm the lay out of radiation kindle be separate into dickens meetings - the sensitizers and protectors. Compounds that extend word picture efektyvinist - sensitizers, the about non qualified of these is the partic number 8 sensitizers of hypoxic prison cells and monoploid pyrimidines. Substances that impose the effectuate of radiation, called protectors. These complicate, for example, cysteine, tsysteanin, hlutationin et al. - totally these substances collapse a sulfhydryl group SH.
group O effect. In the nominal head of molecular(a) atomic number 8 a lot or less all the investigated biologic form is more chutlychymy to roentgen ray and γ-radiation than with opromienni under conditions of start atomic number 8 (hypoxia) or in its absence (anoxia). This home of oxygen gain the specialty of radiation is called oxygen effect and is one of the near innate phenomena in radiobiology. group O quantitatively modifies the issue radiation damage, simply does not compound their quality, it lonesome(prenominal) reduces the social disease of radiation that is essential for the deduction of a circumstantial biological effect: sensitizing by doctor change; sensitising by elektronaktseptornyh properties.
Hypoxic cell sensitizers. These substances pile selectively augment the sensitivity of hypoxic cells to the deadly effect of radiation. They solve on the corresponding belief as that of oxygen and ar effectual elektronaktseptoramy. They atomic number 18 not sensibilize closely oxygenated, ie dominion tissue and be equal to gentle into the tissues much come along than oxygen. Sensitizers are compounds such as quinones, acetophenone, nitrofurans, nitroimidazoles and hlioksali. For example, mizonidazol able to add-on the radiosensitivity of hypoxic cells in tumors of experimental animals 2.5 times. Sensitizers of hypoxic cells use in radiation therapy of tumors.
Protectors. summing up of chemical protecting(prenominal) agents reduces the potency of radiation in the 1.5 - 2 times. To be in force(p) adequacy all over safety-related agents must be point during lance and to be preferably small of engineering science and locations radiotsiynoho damage. Post-radiation of protecting(prenominal) agents are ineffective. By the well-studied group of protective agents include: atomic number 16 and disulfide aminotioly including cysteine, tsystamin, tsysteamin, merkaptoetihunidyn, S-(2-amino-etil)-izotiuroniy-bromide and glutathione. The mechanism of action is to move the hydrogen atom to a release free radical biological, which then reparuyetsya.